I am sorted financially. And he's so supportive my supervisor. I just dread for the day when he'll just snap and kick me out of the lab.
My chapter is moving on. I might even dare say that I now understand why I did the work to begin with. It's a revelation really.
Wednesday, 30 January 2008
Tuesday, 29 January 2008
Intention to submit
I filled in the form that I intend to submit my thesis. That gives me 2 months to finish it....And my super said today: "You must be almost done now?".Hmm, it all depends how one defines the word almost,I guess. I'm meeting him tomorrow for a chat. Let's see how that goes. I'm curious if I'll need to look for a new job when my contract ends in a couple of months.
Monday, 28 January 2008
Tired and stressed
Damn this chapter! I hate it. It never ends and once I read it again, it sounds too weak and make even more changes.
Sunday, 27 January 2008
About competition in science
Public consensus largely beautifies scientific research. One thing that is overlooked it how competitive it really is. Big fish academics compete with each other over who has the most, or any, publications in important journals aka Nature and Science. Then, that all important Nature paper becomes the fish hook for PhD and sometimes project students, that drives them to work like mad, or at least pretend so. And,oh dear, such grief when the paper is rejected and people have to downgrade and send it to a lesser journal. The worst of all, for me, is that they become so full of themselves even at the notion of such recognition. People who are most of the times emotionally immature and cannot cope with either fame or failure. I sincerely worry about some of my colleagues, and wish they could see the forest for the trees. This way they could try to fit some pragmatism into their life plan, and become better scientists in the way. Perhaps even turn into more decent human beings.
Friday, 25 January 2008
Ιστορία εν μέσω πολύ βαρετής ανάλυσης φασματογράφου μάζας
Σκηνικό: σκοτεινή επαρχιακή πόλη Αγγλίας.
Φοιτητικό σπίτι. Χτυπάει η πόρτα. Είναι ο N., πλούσιος κολεγιόπαιδες που μας φορτώνεται συνεχώς ως πρώην συμμαθητής της συγκατοίκου μου.
-Κερδίσαμε παιδιά, κερδίσαμε!
- Τι έγινε, Ν.;
-Κερδίσαμε την υπόθεση του βασιλιά στο ευρωπαϊκό δικαστήριο.
(Η έλλειψη του "πρώην" στη πρόταση του έπρεπε να με είχε υποψιάσει.)
-Ναι, θα τα κρατήσουμε εμείς;
-Τι, τι λες; Κέρδισε ο βασιλιάς, είναι ανθρώπινο δικαίωμα του να κρατήσει την περιουσια της οικογενειας του.
Σε αυτό το σημείο κατάλαβα ότι αν σχεδόν μισό αιώνα μετά τον εμφύλιο και τον διχασμό, ακόμα υπάρχουν δεξιοί και αριστεροί, και σημαίνει κάτι αυτό. Στο περιβάλλον που βρισκόμασταν δεν ήτανε ιδεολογικό το περιεχόμενο της διαφοράς, αλλα μονο θέμα ψυχής.
Επίση κατάλαβα ότι έπρεπε να αλλάξω συγκάτοικο...
Και φυσικά, μερικά χρονια μετά ο πρώην ξεπούλησε την περιουσια της οικογενειας, κουτάλι κουτάλι και πιάτο πιάτο, σε δημοπρασία.
Φοιτητικό σπίτι. Χτυπάει η πόρτα. Είναι ο N., πλούσιος κολεγιόπαιδες που μας φορτώνεται συνεχώς ως πρώην συμμαθητής της συγκατοίκου μου.
-Κερδίσαμε παιδιά, κερδίσαμε!
- Τι έγινε, Ν.;
-Κερδίσαμε την υπόθεση του βασιλιά στο ευρωπαϊκό δικαστήριο.
(Η έλλειψη του "πρώην" στη πρόταση του έπρεπε να με είχε υποψιάσει.)
-Ναι, θα τα κρατήσουμε εμείς;
-Τι, τι λες; Κέρδισε ο βασιλιάς, είναι ανθρώπινο δικαίωμα του να κρατήσει την περιουσια της οικογενειας του.
Σε αυτό το σημείο κατάλαβα ότι αν σχεδόν μισό αιώνα μετά τον εμφύλιο και τον διχασμό, ακόμα υπάρχουν δεξιοί και αριστεροί, και σημαίνει κάτι αυτό. Στο περιβάλλον που βρισκόμασταν δεν ήτανε ιδεολογικό το περιεχόμενο της διαφοράς, αλλα μονο θέμα ψυχής.
Επίση κατάλαβα ότι έπρεπε να αλλάξω συγκάτοικο...
Και φυσικά, μερικά χρονια μετά ο πρώην ξεπούλησε την περιουσια της οικογενειας, κουτάλι κουτάλι και πιάτο πιάτο, σε δημοπρασία.
About today
The weather has been better these past two days, although I haven't been out of the house for at least two weeks. My thesis is now 130 pages and my last experimental chapter almost finished to a high level. I think it''ll be about 160 pages long with 50 pages of appendices.
I had the best dream this morning just before I woke up. I was in Strefi Hill (Λόφος Στρέφη) in Athens and had a walk with V. and A., two friends from uni that have now moved to Barcelona. We chatted and walked and it was summer. I love that place. It's an bizarre Athenian mutant of Park Güell and Green Park, only with the occasional added flavour of dealers and junkies.
Now, I can go back to what my 48th plot in my 54th page of chapter III really means !!???
I had the best dream this morning just before I woke up. I was in Strefi Hill (Λόφος Στρέφη) in Athens and had a walk with V. and A., two friends from uni that have now moved to Barcelona. We chatted and walked and it was summer. I love that place. It's an bizarre Athenian mutant of Park Güell and Green Park, only with the occasional added flavour of dealers and junkies.
Now, I can go back to what my 48th plot in my 54th page of chapter III really means !!???
Thursday, 24 January 2008
Chipped teeth, or how to diagnose periodontal disease using a microchip
Did you ever imagine there would come a time when you could self-diagnose major diseases at home, much like using a home pregnancy test? That day has come one step closer, according to an article in the Proceedings of the National Academy of Sciences (Herr et al, doi:10.1073/pnas.0607254104). It all happened when an oral research and dentistry group at the University of Michigan combined forces with the Biosystems Research Department at Sandia National Laboratories to develop a microfluidics chip that can detect dental disease.
Point-of-care (POC) diagnostics are already part of our every day live. Home pregnancy tests, blood glucose monitors, and sexually transmitted diseases kits are globally used thanks to their fast results. POC tools measure characteristics symptomatic of a particular pathology, known as biomarkers. For example, a high cholesterol level combined with increased blood pressure is indicative of cardiovascular disease.
So how does this chip really work? It detects periodontitis, a chronic inflammatory oral disease caused by bacterial plaque depositions on our teeth. The microchip uses a salivary protein, called matrix metalloproteinase-8 (MM-8), as its biomarker. First, a fluorescent antibody, able bind to MM-8, is loaded onto a porous polyacrylamide gel that forms part of the chip. A mere 20 microlitres of saliva provided by a patient is then poured into the device. MM-8 present in the sample complexes with the antibody, becoming fluorescent itself. An electric potential is subsequently applied to the gel. Charged molecules will separate in bands depending on their size and charge; biochemists routinely use this technique, known as electrophoresis. The distinct bands can finally be identified by fluorescence and the amount of MM-8/antibody fluorescent complex is quantified against standards also present in the gel. High concentrations of MM-8 in saliva are thus indicative of periodontal disease.
The oral diagnostics area is so hot right now that the New York Academy of Sciences is published an entire volume on it (Oral Based Diagnostics, Volume 1098, March 2007, ISBN 1-57331-661-X) with articles from leading scientists, including researchers at the USA National Institute of Health. Tests based on blood have traditionally been considered to convey more information on systemic diseases, like cancer and HIV. However, advances such as this periodontitis chip guide us towards a future where commercially available kits could provide results rapidly, cost-effectively and chiefly from minute sample volumes.
Point-of-care (POC) diagnostics are already part of our every day live. Home pregnancy tests, blood glucose monitors, and sexually transmitted diseases kits are globally used thanks to their fast results. POC tools measure characteristics symptomatic of a particular pathology, known as biomarkers. For example, a high cholesterol level combined with increased blood pressure is indicative of cardiovascular disease.
So how does this chip really work? It detects periodontitis, a chronic inflammatory oral disease caused by bacterial plaque depositions on our teeth. The microchip uses a salivary protein, called matrix metalloproteinase-8 (MM-8), as its biomarker. First, a fluorescent antibody, able bind to MM-8, is loaded onto a porous polyacrylamide gel that forms part of the chip. A mere 20 microlitres of saliva provided by a patient is then poured into the device. MM-8 present in the sample complexes with the antibody, becoming fluorescent itself. An electric potential is subsequently applied to the gel. Charged molecules will separate in bands depending on their size and charge; biochemists routinely use this technique, known as electrophoresis. The distinct bands can finally be identified by fluorescence and the amount of MM-8/antibody fluorescent complex is quantified against standards also present in the gel. High concentrations of MM-8 in saliva are thus indicative of periodontal disease.
The oral diagnostics area is so hot right now that the New York Academy of Sciences is published an entire volume on it (Oral Based Diagnostics, Volume 1098, March 2007, ISBN 1-57331-661-X) with articles from leading scientists, including researchers at the USA National Institute of Health. Tests based on blood have traditionally been considered to convey more information on systemic diseases, like cancer and HIV. However, advances such as this periodontitis chip guide us towards a future where commercially available kits could provide results rapidly, cost-effectively and chiefly from minute sample volumes.
Wednesday, 23 January 2008
Light existentialism: when should I turn on the lights?
It's so gloomy and dark today and it's only 11 am. I have the lights on but there is always this conundrum for me, when do you turn on the lights during the day? It's supposed to be late morning and still light but I can't see enough to read. What's more important: one's comfort (perhaps not going blind) or staying true to social form and turning on the lights when the sun goes down?
Tuesday, 22 January 2008
Monday, 21 January 2008
About Greece
As I have been contemplating the thought of moving back to Greece at some not-so-distant future, I read this great post that everyone considering emigrating to my beautiful home country should read:
http://anatomyofmelancholy.wordpress.com/2005/02/15/for-sale-cushy-job-cigarettes-coffee-essential/
http://anatomyofmelancholy.wordpress.com/2005/02/15/for-sale-cushy-job-cigarettes-coffee-essential/
Thursday, 10 January 2008
"obsessions are like sex, simple and complex" Suede
Thesis, thesis, thesis. It is so tedious that I deeply enjoy it. Today, I re-discovered my passion for the new wave french cinema movement. These auters really knew how to create a dreamy sequence. One more thing, they definetely knew was how to pick their women. My absolute favourite: Anouk Aimée. What a beauty!
( Picture from http://www.filmreference.com/Actors-and-Actresses-A-Ba/Aim-e-Anouk.html)
Monday, 7 January 2008
new beginnings
After an xmas break of epic proportions, I am trying to get back into the thesis mode. I hope this year is better than 2007, that personally fucked me up in any way possible esp. my health. So happy new beginnings to everyone, and don't forget that today could be the start of something amazing and beautiful.
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